Recurrent Miscarriage

A single pregnancy loss can have a significant
emotional impact on women and their partners,
and this impact may increase with
each additional loss.

At Conceive IVF, Our team of Fertility expert and clinical counsellor will help you to understand the reasons and possible treatment to avoid miscarriages in future.

“Our expertise in Genetic testing and counselling, Our High end modular IVF lab environment at par with western standards is well equipped to minimise the damage to gametes to minimise this pregnancy loss in future.”

What is Recurrent Miscarriage

A recurrent miscarriage/recurrent pregnancy loss is the spontaneous loss of two or more pregnancy before 24 weeks of gestation.

Emotional Impact

A single pregnancy loss can have a significant emotional impact on women and their partners, and this impact may increase with each additional loss. You may experience feelings of loss, grief or a sense of failure; this is normal and understandable.

Your partner may feel or react differently from you.


“It may help to talk to your doctor about your feelings.”

Your doctor may suggest certain investigations in order to:

  • Identify the cause of the previous pregnancy loss(es)
  • Recommend or suggest appropriate treatment,
  • Help the doctor to estimate your prognosis (the chance of having a baby in the future)

Investigations that are recommended:
Assessment of your medical and family history:
If you (or your family members) have been diagnosed in the past with one of the following medical conditions, it is important to inform your doctor:

  • Congenital abnormalities (Heart defect, Spina Bifida, Downs Syndrome, other syndromes)
  • Thrombophilia, Thromboembolism (blood clotting problems, Stroke)
  • Polycystic ovarian syndrome (PCOS)
  • Diabetes or Thyroid abnormalities
  • No periods or irregular periods (Amenorrhea or Oligomenorrhea)

Screening for AntiPhospholipid Syndrome (APS):
When you cut your finger, the blood will clot to stop you losing too much blood. Thrombophilia is a condition that makes the blood clot more than it should, can lead pregnancy loss, it is called Antiphospholipid syndrome or APS. Testing for antiphospholipid syndrome (APS) is done by a blood test for lupus anticoagulant, and anticardiolipin and maybe also a 2GPI antibodies.

The results can provide information to: (1) make a diagnosis of APS, (2) show a contributing factor of the pregnancy losses, (3) recommend possible treatment for APS and RPL.

Screening for Thyroid dysfunction:
The thyroid gland produces several hormones involved in many processes in the body. Under-production of thyroid hormones (hypothyroidism) is often found in women with RPL, and may increase the risk for pregnancy loss.

Thyroid antibodies, called TPO antibodies, could lead to thyroid dysfunction and are associated with RPL.

The results of screening can provide information to (1) make a diagnosis of thyroid dysfunction, (2) show a possible cause or contributing factor for the pregnancy losses, (3) recommend possible treatment

Pelvic Examination (usually Trans vaginal ultrasound):
To check the shape of the uterus (womb), a fetus may not be able to develop and this increases the chance of a pregnancy loss. Additional Tests, such as, HYCOSY (Hystero contrast salphingography), Hysteroscopy to diagnose and treat Malformations if any.

Additional investigations :
Like Genetic analysis could be considered based on medical and family history:

Genetic testing on pregnancy tissue (called fetal karyotyping) is not recommended in all cases of RPL, but your doctor might consider it to try to identify the cause of any particular loss.

Genetic testing on both parents (called parental karyotyping) can show a genetic abnormality that does not cause a problem in the parent, but may cause a genetic defect in the fetus.

ANA testing : Antinuclear antibodies are often detected in patients with autoimmune diseases. Studies have shown that ANA can also be detected in some patients with RPL, and therefore testing can be considered to explain a possible cause of the pregnancy loss.

Sperm DNA fragmentation : There is now some evidence that damaged sperm could increase the risk of pregnancy loss.

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Dr Madhuri Roy

IVF specialist and Gynecologist

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